INVESTIGADOR PRINCIPAL
Angel Luís García Otín

EQUIPO
María Teresa Blasco Peiró, Isabel Calvo Cebollero, José Antonio Diarte de Miguel, M Cruz Ferrer Gracia, Georgina Fuentes Ferre, Gabriel Galache Osuna, Ralf Kohler, Eduardo Lezcano Callén, Antonela Lukic, Aida Oliván Viguera, Esther Sánchez Insa, Juan Sanchez- Rubio Lezcano, Marisa Sanz Julve.

Hospital Universitario Miguel Servet

• Biología básica de células progenitoras vasculares.
• Uso de células endoteliales progenitoras circulantes (CEPCs) como biomarcadores de enfermedad cardiovascular.
• Uso de progenitores endoteliales en terapia celular.
• Aplicación de progenitores endoteliales en ingeniería de tejidos.

• Medicina Regenerativa,
• Cardiovascular

• Total artículos publicados con FI 11
• Artículos 1er y 2º cuartil 11
• Artículos 1er y 2º cuartil (ratio) 1
• Factor de Impacto 45,57
• Factor de Impacto medio 4,143
• Proyectos activos 4

• Olivan-Viguera A;Valero MS;Coleman N;Brown BM;Laria C;Divina MM;Galvez JA;az-de-Villegas MD;Wulff H;Badorrey R;Kohler R;
A Novel Pan-Negative-Gating Modulator of KCa2/3 Channels, Fluoro-Di-Benzoate, RA-2, Inhibits Endothelium-Derived Hyperpolarization-Type Relaxation in Coronary Artery and Produces Bradycardia In Vivo
Mol Pharmacol.2014;87(2):338-348. FI: 4,12 Q1

• Coleman N;Brown BM;Olivan-Viguera A;Singh V;Olmstead MM;Valero MS;Kohler R;Wulff H;
New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1
Mol Pharmacol.2014;86(3):342-357. FI: 4,12 Q1

• Waeckel L;Bertin F;Clavreul N;Damery T;Kohler R;Paysant J;Sansilvestri-Morel P;Simonet S;Vayssettes-Courchay C;Wulff H;Verbeuren TJ;Feletou M;
Preserved regulation of renal perfusion pressure by small and intermediate conductance K channels in hypertensive mice with or without renal failure
Pflugers Arch.2014;():-. FI: 3,073 Q2

• Koch HL;Sevelsted-Moller L;Rabjerg M;Larsen D;Hansen TP;Klinge L;Wulff H;Knudsen T;Kjeldsen J;Kohler R;
Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis
J Crohns Colitis.2014;8(11):1378-1391. FI: 3,562 Q2

• Kacik M;Olivan-Viguera A;Kohler R;
Modulation of K(Ca)3.1 channels by eicosanoids, omega-3 fatty acids, and molecular determinants
PLoS One.2014;9(11):-. FI: 3,534 Q1

• Wandall-Frostholm C;Skaarup LM;Sadda V;Nielsen G;Hedegaard ER;Mogensen S;Kohler R;Simonsen U;
Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels
PLoS One.2014;9(5):-. FI: 3,534 Q1

• Qian X;Francis M;Kohler R;Solodushko V;Lin M;Taylor MS;
Positive Feedback Regulation of Agonist-Stimulated Endothelial Ca2+ Dynamics by K(Ca)3.1 Channels in Mouse Mesenteric Arteries
Arteriosclerosis Thrombosis and Vascular Biology.2014;34(1):127. FI: 5,533 Q1

• Gonzalez-Vilchez F, Vazquez de Prada JA, Paniagua MJ, Gomez-Bueno M, Arizon JM, Almenar L, Roig E, Delgado J, Lambert JL, Perez-Villa F, Sanz-Julve ML, Crespo-Leiro M, Segovia J, Lopez-Granados A, Martinez-Dolz L, Mirabet S,Escribano P, Diaz-Molina B, Farrero M, Blasco T.
Use of mTOR inhibitors in chronic heart transplant recipients with renal failure: calcineurin-inhibitors conversion or minimization?
Int J Cardiol.2014;171(1):15-23. FI: 6,175 Q1

• Barge-Caballero E, Almenar-Bonet L, Villa-Arranz A, Pérez-Villa F, Segovia-Cubero J, Delgado-Jiménez J, González-Vilchez F, Manito-Lorite N, De-la-Fuente-Galán L, Brossa-Loidi V, Lambert-Rodríguez JL, Pascual-Figal D, Lage-Gallé E, Arizón-Del-Prado JM, Sanz-Julve M, Muñiz-García J, Crespo-Leiro M.
Impact of short-term mechanical circulatory support with extracorporeal devices on postoperative outcomes after emergency heart transplantation: data from a multi-institutional Spanish cohort.
Int J Cardiol.2014;176(1):86-93. FI: 6,175 Q1

• Crespo-Leiro MG, Delgado-Jiménez J, López L, Alonso-Pulpón L, González-Vilchez F, Almenar-Bonet L, Rábago G, Pérez-Villa F, Paniagua Martín MJ, Arizón Del Prado JM, Sousa-Casasnovas I, Manito-Lorite N, Díaz-Molina B, Pascual-Figal D, Lage-Galle E, Blasco-Peiró T, De la Fuente-Galán L, Muñiz J.
The falling incidence of hematologic cancer after heart transplantation.
Clin Transplant.2014;28(10):1142-1147. FI: 1,486 Q2

• Calderón-Santiago M, Priego-Capote F, Galache-Osuna JG, Luque de Castro MD.
Analysis of serum phospholipid profiles by liquid chromatography-tandem mass spectrometry in high resolution mode for evaluation of atherosclerotic patients.
J Chromatogr A.2014;1371:154-162. FI: 4,258 Q1

• Linares Vicente JA, Lukic A, Ruiz Arroyo JR, Revilla Martí P, Simó Sánchez B.
Combined intracoronary thrombolysis, thrombus aspiration and mesh-covered stent implantation for organized massive thrombus burden in ectatic coronary.
Cardiovasc Interv Ther.2014;29(1):55-59. FI: –

• Proyecto Europeo Programa Marco: Identification and validation of cerebral KCa3.1/KCa2.3 postassium channels a drug targets for the prevention and treatment of cerebral ischemia associated with diabetes and Alzheimers disease (BrainIK). IP: Kohler, Ralf
• Proyecto fondos propios: T cell channelosomics in multiple sclerosis (CHANNELOSOMICS) IP: Kohler, Ralf
• Proyecto fondos propios: Strategies to promote vascularization in skeletal muscle tissue engineered constructs (VEMT). IP. García Otín, Ángel Luis
• Contrato-convenio de investigación: Estudio epidemiológico de estimación del impacto personal y social del trasplante cardiaco. Estudio QUAINT. IP: Sanz Julve, Marisa

• Grupo Emergente de investigación aplicada de la DGA “Progenitores adultos del sistema cardiovascular (GIPASC)”.