EpiChron: Investigación en enfermedades crónicas
Grupos de investigación

En EpiChron investigamos en cronicidad y multimorbilidad para generar evidencia científica que sea útil para mejorar la atención y salud de las personas con enfermedades crónicas
Equipo Científico
INVESTIGADOR PRINCIPAL
EQUIPO
Beatriz Poblador, Clara Laguna (Estadísticas); Paula Ara (Veterinaria); Alejandro Santos (Bioinformático); Andrea Jimeno (Nutricionista); Belén Cruces (Matemática); Aida Moreno, Luis Gimeno (Medicina Familiar y Comunitaria); Mercedes Aza, Ana Bandrés, Belén Pina (Farmacéuticas); Mercedes Clerencia, Carmen Elías (Geriatras); Jesús Díez (Internista); Mayte Clares (Enfermería); Mabel Cano, Kevin Bliek, Inmaculada Guerrero (Medicina Preventiva y Salud Pública); Antonio Poncel (Médico Sistemas de Información); Amaia Calderón, Ignatios Ioakeim (colaboradores internacionales).
EpiChron es un grupo de investigación multidisciplinar de profesionales clínicos y de salud pública del sistema de salud de Aragón centrado en la caracterización clínico-epidemiológica de las enfermedades crónicas y la multimorbilidad, investigando su naturaleza, evolución e impacto en la población a través del uso de datos de vida real y su abordaje mediante modelos de atención centrados en la persona.
Página web del grupo
Actividad del grupo de investigación
EpiChron es un grupo de investigación multidisciplinar del Sistema Nacional de Salud centrado en la caracterización clínico-epidemiológica de las enfermedades crónicas y la multimorbilidad a través del uso de datos de vida real y su abordaje mediante modelos de atención centrados en la persona.
Centro
Programas
- Salud pública, cronicidad, servicios sanitarios y atención primaria
Líneas de investigación
- Caracterización de enfermedades crónicas y multimorbilidad: Enfoque poblacional a través de la Cohorte EpiChron y utilización de datos de vida real en investigación (FAIR4Health H2020)
- Abordaje de la multimorbilidad centrado en la persona: Ensayo clínico MULTIPAP Study
- Diseño de modelos de respuesta a la cronicidad: Principios Ariadne e Integrated Multimorbidity Care Model (EU Chrodis Joint Action)
- Caracterización clínico-epidemiológica de COVID19 (PRECOVID Study)
Actividad y resultados más relevantes del año
PROYECTOS Y REDES DE INVESTIGACIÓN
EpiChron participa en la Joint Action europea JACARDI sobre prevención de enfermedades cardiovasculares y diabetes, coordinando la implementación de tres proyectos piloto en Aragón. Además, en el marco de la red de colaboración europea de investigación en vacunas VAC4EU, trabajamos en seis proyectos de seguridad y eficacia de las vacunas COVID19 y VRS.
A nivel nacional, en 2024 EpiChron ha reacreditado su participación en la Red de Investigación en Cronicidad, Atención Primaria y Promoción de la Salud (RICAPPS), donde lidera el paquete de trabajo sobre caracterización de la cronicidad, multimorbilidad y fragilidad, participando en proyectos colaborativos financiados por el ISCIII como LOXO (trayectorias de multimorbilidad), SURBCAN (cáncer de mama) y triaje de personas mayores en urgencias. Además, EpiChron es Grupo de Referencia reconocido por el Gobierno de Aragón (B01_23R).
Asimismo, tenemos en desarrollo estudios sobre multimorbilidad relacionados con los determinantes sociales e interseccionalidad, inflamación crónica de bajo grado, EPOC, VIH, enfermedades dermatológicas y salud perinatal.
DOCENCIA Y FORMACIÓN
EpiChron es unidad acreditada del dispositivo docente para formación especializada MIR de MPySP, y ha firmado en 2024 un acuerdo de rotaciones con la UD Multiprofesional de AFyC del Sector III que se suma al acuerdo de colaboración de rotaciones internas con el Servicio de Dermatología del HUMS. Asimismo, este año hemos recibido la estancia durante cuatro meses de una geriatra R4 de la Universidad de Brescia y tres investigadores del grupo han realizado estancias externas. Se ha defendido una tesis doctoral, y cuatro están en desarrollo.
RRHH
El mayor hito para el grupo en 2024 ha sido la obtención de un contrato Juan Rodés por parte de una investigadora especialista en MFyC, que le permitirá compatibilizar su actividad asistencial con la investigación clínica en multimorbilidad. Además, el grupo tiene 5 contratos de apoyo a la investigación asociados a la Red RICAPPS, JACARDI, Programa Investigo y fondos propios.
Artículos publicados
Vacío
2024
Moreno-Juste A, et al. Multimorbidity in Patients with Chronic Liver Disease: A Population-Based Study in the EpiChron Cohort, Spain. J Clin Med. 2024 Nov 27;13(23):7198. https://doi.org/10.3390/jcm13237198
Moreno-Juste A, et al. Intersectional analysis of social determinants of health and their association with mortality in patients with multimorbidity. J Glob Health. 2024 Oct 18;14:04229. https://doi.org/10.7189/jogh.14.04229
Santos-Mejías A, et al. Unveiling the comorbidity burden of male breast cancer. Sci Rep. 2024 Oct 3;14(1):22977. https://doi.org/10.1038/s41598-024-73032-4
Gini R, et al. Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Lessons Learnt From the MINERVA Project in Europe. Pharmacoepidemiol Drug Saf. 2024 Aug;33(8):e5884. https://doi.org/10.1002/pds.5884
Pajouheshnia R, et al. Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Development and Pilot of a Metadata List and Catalogue in Europe. Pharmacoepidemiol Drug Saf. 2024 Aug;33(8):e5871. https://doi.org/10.1002/pds.5871
Hurley E, et al. COVID-19 and pregnancy: A European study on pre- and post-infection medication use. Eur J Clin Pharmacol. 2024 May;80(5):707-716. https://doi.org/10.1007/s00228-024-03639-z
Gracia Gutiérrez A, et al. Multimorbidity in Incident Heart Failure: Characterisation and Impact on 1-Year Outcomes. J Clin Med. 2024 Jul 8;13(13):3979. https://doi.org/10.3390/jcm13133979
Ioakeim-Skoufa I, et al. Multimorbidity patterns and trajectories in young and middle-aged adults: a large-scale population-based cohort study. Front Public Health. 2024 May 16;12:1349723. https://doi.org/10.3389/fpubh.2024.1349723
Moreno-Juste A, et al. Mental health and risk of death and hospitalization in COVID-19 patients. Results from a large-scale population-based study in Spain. PLoS One. 2024 Feb 12;19(2):e0298195. https://doi.org/10.1371/journal.pone.0298195
Abbad-Gomez D, et al. Effect of comorbidity and multimorbidity on adherence to follow-up recommendations among long-term breast cancer survivors. Maturitas. 2024 Jan 20;182:107918. https://doi.org/10.1016/j.maturitas.2024.107918
Almenara-Blasco M, et al. Multimorbidity of Psoriasis: A Large-Scale Population Study of Its Associated Comorbidities. J Clin Med. 2024 Jan 16;13(2):492. https://doi.org/10.3390/jcm13020492
2023
Moreno-Juste A, et al. Multimorbidity, social determinants and intersectionality in chronic patients. Results from the EpiChron Cohort. J Glob Health. 2023;13:04014. https://doi.org/10.7189/13.04014
Ioakeim-Skoufa I, et al. Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials. Cancers (Basel). 2023 May 30;15(11):2972. https://doi.org/10.3390/cancers15112972
Lutomski JE, et al. Multimorbidity patterns in older persons and their association with self-reported quality of life and limitations in activities of daily living. Arch Gerontol Geriatr. 2023 Jul 20;115:105134. https://doi.org/10.1016/j.archger.2023.105134
Lleal M, et al. Multimorbidity patterns in COVID-19 patients and their relationship with infection severity: MRisk-COVID study. PLoS One. 2023 Aug 31;18(8):e0290969. https://doi.org/10.1371/ journal.pone.0290969
Sinaci AA, et al. A Data Transformation Methodology to Create Findable, Accessible, Interoperable, and Reusable Health Data: Software Design, Development, and Evaluation Study. J Med Internet Res. 2023 Mar 8;25:e42822. https://doi.org/10.2196/42822
2022
Lozano-Hernández CM, López-Rodríguez JA, Rico-Blázquez M, et al. Sex differences in social support perceived by polymedicated older adults with multimorbidity. MULTIPAP study. PLoS One. 2022;17(7):e0268218. Published 2022 Jul 27. doi:10.1371/journal.pone.0268218
Malo S, Maldonado L, Rabanaque MJ, et al. Patterns of statin adherence in primary cardiovascular disease prevention during the pandemic. Front Pharmacol. 2022;13:980391. Published 2022 Nov 14.
doi:10.3389/fphar.2022.980391
Almenara-Blasco M, Carmona-Pírez J, Gracia-Cazaña T, et al. Comorbidity Patterns in Patients with Atopic Dermatitis Using Network Analysis in the EpiChron Study. Journal of Clinical Medicine. 2022;
11(21):6413. https://doi.org/10.3390/jcm11216413
Reus, X.; Sastre, M.L.; Leiva, A.; et al. C. LESS-PHARMA Study: Identifying and Deprescribing Potentially
Inappropriate Medication in the Elderly Population with Excessive Polypharmacy in Primary Care. Int. J. Environ. Res. Public Health 2022, 19, 13241. https://
doi.org/10.3390/ijerph192013241
Ioakeim-Skoufa, I.; Clerencia-Sierra, M.; Moreno-Juste, A.; et al. Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort. Int. J. Environ. Res. Public Health 2022, 19, 10180. https://doi.
org/10.3390/ijerph191610180
Gracia Gutiérrez A, Grados Saso D, Esteban Cabello EI, et al. Clinical characteristics of heart failure patients with mid-range ejection fraction. Acta Cardiol. 2022 Aug 10:1-8. doi: 10.1080/00015385.2022.2059135. Epub ahead of print. PMID: 35947112.
Del Cura-González I, López-Rodríguez JA, Leiva-Fernández F, et al; Effectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial. Trials. 2022 Jun 9; 23(1):479. doi: 10.1186/s13063-022-06293-x. PMID:
35681224; PMCID: PMC9178530.
Del Cura-González I, López-Rodríguez JA, Leiva-Fernández F, et al. How to Improve Healthcare for Patients with Multimorbidity and Polypharmacy in Primary Care: A Pragmatic Cluster-Randomized Clinical
Trial of the MULTIPAP Intervention. J Pers Med. 2022 May 6;12(5):752. doi: 10.3390/jpm12050752. PMID:
35629175; PMCID: PMC9144280
Santiá P, Jansana A, Del Cura I, et al. Adherence of long-term breast cancer survivors to follow-up care guidelines: a study based on real-world data from the
SURBCAN cohort. Breast Cancer Res Treat. 2022 Mar 15. doi: 10.1007/s10549-022-06563-x. Epub ahead of print. PMID: 35290544.
Carmona-Pírez, J.; Ioakeim-Skoufa, I.; Gimeno-Miguel, A.; et al. Multimorbidity Profiles and Infection Severity in COVID-19 Population Using Network Analysis in
the Andalusian Health Population Database. Int. J. Environ. Res. Public Health 2022, 19, 3808. https://
doi.org/10.3390/ijerph19073808
Carmona-Pírez J, Gimeno-Miguel A, Bliek-Bueno K, et al. Identifying multimorbidity profiles associated with COVID-19 severity in chronic patients using network analysis in the PRECOVID Study. Sci Rep. 2022 Feb
18;12(1):2831. doi: 10.1038/s41598-022-06838-9. PMID: 35181720; PMCID: PMC8857317.
Carmona-Pírez J, Poblador-Plou B, Poncel-Falcó A, et al. Applying the FAIR4Health Solution to Identify Multimorbidity Patterns and Their Association with Mortality through a Frequent Pattern
Growth Association Algorithm. International Journal of Environmental Research and Public Health. 2022; 19(4):2040. https://doi.org/10.3390/ijerph19042040
2021
Gencturk M, Teoman A, Alvarez-Romero C, Martinez-Garcia A, Parra-Calderon CL, Poblador-Plou B, Löbe M, Sinaci AA. End User Evaluation of the FAIR4Health Data Curation Tool. Stud Health Technol Inform. 2021 May 27;281:8-12.
Gimeno-Miguel A, Bliek-Bueno K, Poblador-Plou B, Carmona-Pírez J, Poncel-Falcó A, González-Rubio F, et al. (2021) Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study. PLoS ONE 16(11): e0259822.
Bliek-Bueno K, Mucherino S, Poblador-Plou B, González-Rubio F, Aza-Pascual-Salcedo M, Orlando V, Clerencia-Sierra M, Ioakeim-Skoufa I, Coscioni E, Carmona-Pírez J, Perrella A, Trama U, Prados-Torres A, Menditto E, Gimeno-Miguel A. Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy. International Journal of Environmental Research and Public Health. 2021; 18(22):11786.
Jansana A, Poblador-Plou B, Gimeno-Miguel A, Lanzuela M, Prados-Torres A, Domingo L, Comas M, Sanz-Cuesta T, Del Cura-Gonzalez I, Ibañez B, Abizanda M, Duarte-Salles T, Padilla-Ruiz M, Redondo M, Castells X, Sala M; SURBCAN Group. Multimorbidity clusters among long-term breast cancer survivors in Spain: Results of the SURBCAN study. Int J Cancer. 2021 Jul 13
Leiva-Fernández, F., González-Hevilla, A., Prados-Torres, J. D., Casas-Galán, F., García-Domingo, E., Ortiz-Suárez, P., López-Rodríguez, J. A., & Pico-Soler, M. V. (2021). Identification of the multimorbidity training needs of primary care professionals: Protocol of a survey. Journal of Multimorbidity and Comorbidity.
Eloísa Rogero-Blanco, Isabel Del-Cura-González, Mercedes Aza-Pascual-Salcedo, Francisca García de Blas González, Carmen Terrón-Rodas, Sergio Chimeno-Sánchez, Eva García-Domingo, Juan A. López-Rodríguez & group MULTIPAP (2021) Drug interactions detected by a computer-assisted prescription system in primary care patients in Spain: MULTIPAP study, European Journal of General Practice, 27:1, 90-96
Mucherino S, Gimeno-Miguel A, Carmona-Pirez J, Gonzalez-Rubio F, Ioakeim-Skoufa I, Moreno-Juste A, Orlando V, Aza-Pascual-Salcedo M, Poblador-Plou B, Menditto E, Prados-Torres A. Changes in Multimorbidity and Polypharmacy Patterns in Young and Adult Population over a 4-Year Period: A 2011-2015 Comparison Using Real-World Data. Int J Environ Res Public Health. 2021 Apr 21;18(9):4422.
Jansana A, Domingo L, Ibañez B, Prados A, Del Cura I, Padilla-Ruiz M, Sanz T, Poblador B, Tamayo I, Gimeno A, Alberquilla A, Abizanda M, Comas M, Lanzuela M, Burgui R, Holgado AD, Duarte-Salles T, Moreno C, Louro J, Baquedano J, Molina C, Del Carmen Martinez M, Gorricho J, Redondo M, Castells X, Sala M. Use of health services among long-term breast cancer survivors in Spain: longitudinal study based on real-world data. J Cancer Surviv. 2021 Mar 23.
Carmona-Pírez J, Poblador-Plou B, Ioakeim-Skoufa I, González-Rubio F, Gimeno-Feliú LA, Díez-Manglano J, Laguna-Berna C, Marin JM, Gimeno-Miguel A, Prados-Torres A. Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort. Sci Rep. 2021 Feb 26;11(1):4784.
Gimeno-Feliu LA, Pastor-Sanz M, Poblador-Plou B, Calderón-Larrañaga A, Díaz E, Prados-Torres A. Overuse or underuse? Use of healthcare services among irregular migrants in a north-eastern Spanish region. Int J Equity Health. 2021 Jan 20;20(1):41.
2020-2018
2020
Guerrero Fernández de Alba I, Gimeno-Miguel A, Poblador-Plou B, Gimeno-Feliu LA, Ioakeim-Skoufa I, Rojo-Martínez G, Forjaz MJ, Prados-Torres A. Association between mental health comorbidity and health outcomes in type 2 diabetes mellitus patients. Sci Rep. 2020 Nov 11;10(1):19583. doi: 10.1038/s41598-020-76546-9
Guerrero Fernández de Alba, I., Gimeno-Miguel, A., Poblador-Plou, B. et al. Association between mental health comorbidity and health outcomes in type 2 diabetes mellitus patients. Sci Rep 10, 19583 (2020). https://doi.org/10.1038/s41598-020-76546-9
Carmona-Pírez J, Poblador-Plou B, Díez-Manglano J, Morillo-Jiménez MJ, Marín Trigo JM, Ioakeim-Skoufa I, Gimeno-Miguel A, Prados-Torres A. Multimorbidity networks of chronic obstructive pulmonary disease and heart failure in men and women: Evidence from the EpiChron Cohort. Mech Ageing Dev. 2020 Oct 29;193:111392. doi: 10.1016/j.mad.2020.111392. Epub ahead of print. PMID: 33129797.
Guerrero Fernández de Alba, I., Gimeno-Miguel, A., Poblador-Plou, B. et al. Association between mental health comorbidity and health outcomes in type 2 diabetes mellitus patients. Sci Rep 10, 19583 (2020). https://doi.org/10.1038/s41598-020-76546-9
Díez-Manglano J, Berges Vidal M, Martínez Barredo L, Poblador-Plou B, Gimeno-Miguel A, Martínez Heras P, Prados-Torres A. Chronic Obstructive Pulmonary Disease and Incidence of Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort. Int J Chron Obstruct Pulmon Dis. 2020;15:2799-2806 https://doi.org/10.2147/COPD.S270713
Leiva-Fernández F, Prados-Torres JD, Prados-Torres A, Del-Cura-González I, Castillo-Jimena M, López-Rodríguez JA, Rogero-Blanco ME, López-Verde F, Bujalance-Zafra MJ, Pico-Soler MV, Gimeno-Feliu LA, Poblador-Plou B, Martinez-Cañavate MT, Muth C; MULTIPAP Group. Training primary care professionals in multimorbidity management: educational assessment of the eMULTIPAP course. Mech Ageing Dev. 2020 Sep 15:111354. doi: 10.1016/j.mad.2020.111354. Epub ahead of print. PMID: 32946885.
Jansana A, Del Cura I, Prados-Torres A, Sanz Cuesta T, Poblador-Plou B, Gimeno Miguel A, Lanzuela M, Ibañez B, Tamayo I, Moreno-Iribas C, Padilla-Ruiz M, Redondo M, Comas M, Domingo L, Díaz-Holgado A, Salamanca FJ, Castells X, Sala M; SURBCAN group. Use of real-world data to study health services utilisation and comorbidities in long-term breast cancer survivors (the SURBCAN study): study protocol for a longitudinal population-based cohort study. BMJ Open. 2020 Sep 9;10(9):e040253. doi: 10.1136/bmjopen-2020-040253. PMID: 32912957; PMCID: PMC7482495.
Lopez-Rodriguez JA, Rogero-Blanco E, Aza-Pascual-Salcedo M, Lopez-Verde F, Pico-Soler V, Leiva-Fernandez F, Prados-Torres JD, Prados-Torres A, Cura-González I; MULTIPAP group. Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study. PLoS One. 2020 Aug 12;15(8):e0237186. doi: 10.1371/journal.pone.0237186. PMID: 32785232.
Francisca González-Rubio, Ignatios Ioakeim-Skoufa, Beatriz Poblador-Plou, Antonio Gimeno-Miguel, Alexandra Prados-Torres, Influenza vaccination: an ally to mitigate influenza-associated risks during the coronavirus pandemics, Clinical Infectious Diseases, , ciaa1190, https://doi.org/10.1093/cid/ciaa1190
Letosa-Gaudó J, González-Rubio F, Ioakeim-Skoufa I. Analytical errors due to biotin interference. Med Clin (Barc). 2020 Jul 24:S0025-7753(20)30440-1. English, Spanish. doi: 10.1016/j.medcli.2020.04.049. Epub ahead of print. PMID: 32718712.
Rodriguez-Blazquez C, João Forjaz M, Gimeno-Miguel A, Bliek-Bueno K, Poblador-Plou B, Pilar Luengo-Broto S, Guerrero-Fernández de Alba I, Maria Carriazo A, Lama C, Rodríguez-Acuña R, Cosano I, Bedoya JJ, Angioletti C, Carfì A, Di Paola A, Navickas R, Jureviciene E, Dambrauskas L, Liseckiene I, Valius L, Urbonas G, Onder G, Prados-Torres A. Assessing the Pilot Implementation of the Integrated Multimorbidity Care Model in Five European Settings: Results from the Joint Action CHRODIS-PLUS. Int J Environ Res Public Health. 2020 Jul 22;17(15):E5268. doi: 10.3390/ijerph17155268. PMID: 32707791.
Poblador-Plou B, Carmona-Pírez J, Ioakeim-Skoufa I, Poncel-Falcó A, Bliek-Bueno K, Cano-Del Pozo M, Gimeno-Feliú LA, González-Rubio F, Aza-Pascual-Salcedo M, Bandrés-Liso AC, Díez-Manglano J, Marta-Moreno J, Mucherino S, Gimeno-Miguel A, Prados-Torres A, EpiChron Group. Baseline Chronic Comorbidity and Mortality in Laboratory-Confirmed COVID-19 Cases: Results from the PRECOVID Study in Spain. Int J Environ Res Public Health. 2020 Jul 17;17(14):E5171. doi: 10.3390/ijerph17145171. PMID: 32709002.
Lozano-Hernández CM, López-Rodríguez JA, Leiva-Fernández F, Calderón-Larrañaga A, Barrio-Cortes J, Gimeno-Feliu LA, Poblador-Plou B, Cura-González ID; MULTIPAP GROUP. Social support, social context and nonadherence to treatment in young senior patients with multimorbidity and polypharmacy followed-up in primary care. MULTIPAP Study. PLoS One. 2020 Jun 24;15(6):e0235148. doi: 10.1371/journal.pone.0235148. PMID: 32579616; PMCID: PMC7314051.
Gimeno-Feliu LA, Pastor-Sanz M, Poblador-Plou B, Calderón-Larrañaga A, Díaz E, Prados-Torres A. Multimorbidity and chronic diseases among undocumented migrants: evidence to contradict the myths. Int J Equity Health. 2020 Jul 6;19(1):113. doi: 10.1186/s12939-020-01225-0. PMID: 32631325; PMCID: PMC7336489.
Ioakeim-Skoufa I, Poblador-Plou B, Carmona-Pírez J, Díez-Manglano J, Navickas R, Gimeno-Feliu LA, González-Rubio F, Jureviciene E, Dambrauskas L, Prados-Torres A, Gimeno-Miguel A. Multimorbidity Patterns in the General Population: Results from the EpiChron Cohort Study. Int J Environ Res Public Health. 2020 Jun 14;17(12):4242. doi: 10.3390/ijerph17124242. PMID: 32545876; PMCID: PMC7345112.
Gilaberte Y, Pérez-Gilaberte JB, Poblador-Plou B, Bliek-Bueno K, Gimeno-Miguel A, Prados-Torres A. Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data. J Clin Med. 2020 May 28;9(6):1632. doi: 10.3390/jcm9061632. PMID: 32481591; PMCID: PMC7356227.
Moreno-Juste A, Poblador-Plou B, Aza-Pascual-Salcedo M, González-Rubio F, Malo S, Librero López J, Pico-Soler V, Giménez Labrador E, Mucherino S, Orlando V, Menditto E, Prados-Torres A, Gimeno-Miguel A. Initial Therapy, Regimen Change, and Persistence in a Spanish Cohort of Newly Treated Type 2 Diabetes Patients: A Retrospective, Observational Study Using Real-World Data. Int J Environ Res Public Health. 2020 May 25;17(10):3742. doi: 10.3390/ijerph17103742. PMID: 32466267; PMCID: PMC7277774
Clerencia-Sierra M, Ioakeim-Skoufa I, Poblador-Plou B, González-Rubio F, Aza-Pascual-Salcedo M, Gimeno-Miguel MMA, Prados-Torres A. Do Centenarians Die Healthier than Younger Elders? A Comparative Epidemiological Study in Spain. J Clin Med. 2020 May 21;9(5):1563. doi: 10.3390/jcm9051563. PMID: 32455809; PMCID: PMC7291259.
Rogero-Blanco E, Lopez-Rodriguez JA, Sanz-Cuesta T, Aza-Pascual-Salcedo M, Bujalance-Zafra MJ, Cura-Gonzalez I; MultiPAP Group. Use of an Electronic Clinical Decision Support System in Primary Care to Assess Inappropriate Polypharmacy in Young Seniors With Multimorbidity: Observational, Descriptive, Cross-Sectional Study. JMIR Med Inform. 2020 Mar 3;8(3):e14130. doi: 10.2196/14130. PMID: 32149715; PMCID: PMC7078622.
Machón M, Mateo-Abad M, Clerencia-Sierra M, Güell C, Poblador-Pou B, Vrotsou K, Gimeno-Miguel A, Prados-Torres A, Vergara I. Multimorbidity and functional status in older people: a cluster analysis. Eur Geriatr Med. 2020 Apr;11(2):321-332. doi: 10.1007/s41999-020-00291-5. Epub 2020 Feb 17. PMID: 32297200.
Gracia Gutiérrez A, Poblador-Plou B, Prados-Torres A, Ruiz Laiglesia FJ, Gimeno-Miguel A. Sex Differences in Comorbidity, Therapy, and Health Services’ Use of Heart Failure in Spain: Evidence from Real-World Data. Int J Environ Res Public Health. 2020 Mar 23;17(6):2136. doi: 10.3390/ijerph17062136. PMID: 32210137; PMCID: PMC7143043.
Orlando V, Monetti VM, Moreno Juste A, Russo V, Mucherino S, Trama U, Guida A, Menditto E. Drug Utilization Pattern of Antibiotics: The Role of Age, Sex and Municipalities in Determining Variation. Risk Manag Healthc Policy. 2020 Jan 29;13:63-71. doi: 10.2147/RMHP.S223042. PMID: 32099490; PMCID: PMC6996207.
2019
Palmer K, Carfì A, Angioletti C, Di Paola A, Navickas R, Dambrauskas L, Jureviciene E, João Forjaz M, Rodriguez-Blazquez C, Prados-Torres A, Gimeno-Miguel A, Cano-Del Pozo M, Bestué-Cardiel M, Leiva-Fernández F, Poses Ferrer E, Carriazo AM, Lama C, Rodríguez-Acuña R, Cosano I, Bedoya-Belmonte JJ, Liseckiene I, Barbolini M, Txarramendieta J, de Manuel Keenoy E, Fullaondo A, Rijken M, Onder G. A Methodological Approach for Implementing an Integrated Multimorbidity Care Model: Results from the Pre-Implementation Stage of Joint Action CHRODIS-PLUS. Int J Environ Res Public Health. 2019 Dec 11;16(24):5044. doi: 10.3390/ijerph16245044. PMID: 31835691; PMCID: PMC6950053.
Gimeno-Miguel A, Gracia Gutiérrez A, Poblador-Plou B, Coscollar-Santaliestra C, Pérez-Calvo JI, Divo MJ, Calderón-Larrañaga A, Prados-Torres A, Ruiz-Laiglesia FJ. Multimorbidity patterns in patients with heart failure: an observational Spanish study based on electronic health records. BMJ Open. 2019 Dec 23;9(12):e033174. doi: 10.1136/bmjopen-2019-033174. PMID: 31874886; PMCID: PMC7008407.
Forjaz MJ, Rodriguez-Blazquez C, Guerrero-Fernández de Alba I, Gimeno-Miguel A, Bliek-Bueno K, Prados-Torres A, The Chrodis Expert Group On Multimorbidity OBO. Application of the JA-CHRODIS Integrated Multimorbidity Care Model (IMCM) to a Case Study of Diabetes and Mental Health. Int J Environ Res Public Health. 2019 Dec 17;16(24):5151. doi: 10.3390/ijerph16245151. PMID: 31861096; PMCID: PMC6950036.
Moreno Juste A, Menditto E, Orlando V, Monetti VM, Gimeno Miguel A, González Rubio F, Aza-Pascual-Salcedo MM, Cahir C, Prados Torres A, Riccardi G. Treatment Patterns of Diabetes in Italy: A Population-Based Study. Front Pharmacol. 2019 Aug 6;10:870. doi: 10.3389/fphar.2019.00870. PMID: 31447672; PMCID: PMC6691351.
Gimeno-Miguel A, Clerencia-Sierra M, Ioakeim I, Poblador-Plou B, Aza-Pascual-Salcedo M, González-Rubio F, Rodríguez Herrero R, Prados-Torres A. Health of Spanish centenarians: a cross-sectional study based on electronic health records. BMC Geriatr. 2019 Aug 19;19(1):226. doi: 10.1186/s12877-019-1235-7. PMID: 31426764; PMCID: PMC6701024.
Forns J, Cainzos-Achirica M, Hellfritzsch M, Morros R, Poblador-Plou B, Hallas J, Giner-Soriano M, Prados-Torres A, Pottegård A, Cortés J, Castellsagué J, Jacquot E, Deltour N, Perez-Gutthann S, Pladevall M. Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources. Pharmacoepidemiol Drug Saf. 2019 Jul;28(7):965-975. doi: 10.1002/pds.4803. Epub 2019 Jun 6. PMID: 31172633; PMCID: PMC6618105.
Jansana A, Posso M, Guerrero I, Prados-Torres A, Del Cura MI, Castells X, Sala M. Health care services use among long-term breast cancer survivors: a systematic review. Journal of Cancer Survivorship 2019.
Manel Pladevall‑Vila, Anton Pottegård, Tania Schink, Johan Reutfors, Rosa Morros, Beatriz Poblador‑Plou, Antje Timmer, Joan Forns, Maja Hellfritzsch, Tammo Reinders, David Hägg, ·Maria Giner‑Soriano, Alexandra Prados-Torres, Miguel Cainzos‑Achirica, Jesper Hallas, Lena Brandt, Jordi Cortés, Jaume Aguado, Gabriel Perlemuter, Bruno Falissard, Jordi Castellsagué, Emmanuelle Jacquot, Nicolas Deltour, Susana Perez‑ Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users in Four European Countries: A Cohort and Nested Case–Control Study Using Automated Health Data Sources CNS Drugs Apr;33(4):383-395. 2019
Luis Andrés Gimeno-Feliu, Amaia Calderón-Larrañaga, Esperanza Díaz, Clara Laguna-Berna,Beatriz Poblador-Plou, Carlos Coscollar-Santaliestra and Alexandra Prados-Torres. The definition of immigrant status matters: impact of nationality, country of origin, and length of stay in host country on mortality estimates. BMC Public Health 19:247;
Joan Forns, Anton Pottegård, Tammo Reinders, Beatriz Poblador-Plou, Rosa Morros, Lena Brandt, Miguel Cainzos-Achirica, Maja Hellfritzsch, Tania Schink, Alexandra Prados Torres, Maria Giner-Soriano, David Hägg, Jesper Hallas, Jordi Cortés, Emmanuelle Jacquot, Nicolas Deltour, Susana Perez-Gutthann, Manel Pladevall, Johan Reutfors. Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: incidence and comorbidities of initiators. Journal of Affective Disorders 249; 242-252. 2019
Enrica Menditto, Antonio Gimeno Miguel, Aida Moreno, Beatriz Poblador Plou, Mercedes Aza, Valentina Orlando, Francisca González Rubio, Alexandra Prados-Torres. Patterns of multimorbidity and polypharmacy in young and adult population: Systematic associations among chronic diseases and drugs using factor analysis. Plos One 6;14(2). 2019.
2018
Aida Moreno Juste, Antonio Gimeno Miguel, Beatriz Poblador Plou, Francisca González Rubio, María Mercedes Aza Pascual-Salcedo, Enrica Menditto, Alexandra Prados Torres. Adherencia al tratamiento de hipertensión arterial,hipercolesterolemia y diabetes en población anciana de una cohorte española. Medicina Clínica 2018.
Divo MJ, Celli BR, Poblador-Plou B, Calderón-Larrañaga A, de-Torres JP, Gimeno-Feliu LA, Bertó J, Zulueta JJ, Casanova C, Pinto-Plata VM, Cabrera-Lopez C, Polverino F, Carmona Píréz J, Prados-Torres A, Marin JM; EpiChron—BODE Collaborative Group. Chronic Obstructive Pulmonary Disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort. PLoS One. 2018
Elisa Martín-Merino, Amaia Calderón-Larrañaga, Samuel Hawley, Beatriz Poblador-Plou, Ana Llorente, Irene Petersen, and Daniel Prieto-Alhambra. The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multi-database multinational population-based cohort study. Clinical Epidemiology 10, 643-654. 2018
Prados-Torres A, Poblador-Plou B, Gimeno-Miguel A, Calderón-Larrañaga A, Poncel-Falcó A, Gimeno-Feliú LA, González-Rubio F, Laguna-Berna C, Marta-Moreno J, Clerencia-Sierra M, Aza-Pascual-Salcedo M, Bandrés-Liso AC, Coscollar-Santaliestra C, Pico-Soler V, Abad-Díez JM. Cohort Profile: The Epidemiology of Chronic Diseases and Multimorbidity. The EpiChron Cohort Study. International Journal Epidemiology 47(2), 382-384 2018
Geurtje Maria Wijers I, Ayala A, Rodriguez-Blazquez C, Rodriguez-Laso A, Rodriguez-García P, Prados-Torres A, Rodriguez-Rodriguez V, Joao Forjaz M. The Disease Burden Morbidity Assessment in older adults and its association with mortality and other health outcomes. European Jourmal of 2018
Davide L Vetrano, Amaia Calderón-Larrañaga, Alessandra Marengoni, Graziano Onder, Jürgen M Bauer, Matteo Cesari, Luigi Ferrucci, Laura Fratiglioni. An international perspective on chronic multimorbidity: approaching the elephant in the room. J Gerontol A Biol Sci Med Sci, Vol. 73, No. 10, 1350-1356. 2018
Enrica Menditto, Caitriona Cahir, Mercedes Aza, Dario Bruzzese, Beatriz Poblador-Plou, Sara Malo, Elisio Costa, Francisca González-Rubio, Antonio Gimeno-Miguel, Valentina Orlando, Przemislaw Kardas, Alexandra Prados-Torres. Adherence in chronic medication in older populations: application of a common protocol among three European Countries. Patient Preference and Adherence 12, 1975-1987. 2018
Jordi Castellsague, Beatriz Poblador‐Plou, Maria Giner‐Soriano, Marie Linder, Oliver Scholle, Brian Calingaert, Christine Bui, Alejandro Arana, Clara Laguna, Francisca Gonzalez‐Rubio, Albert Roso‐Llorach, Alexandra Prados‐Torres, Susana Perez‐Gutthann. Effectiveness of risk-minimization measures for the use of cilostazol in United Kingdom, Spain, Sweden, and Germany. Pharmacoepidemiology & Drug Safety 27(9):953-961. 20
Palmer K,Marengoni A, Forjaz MJ, Jureviciene E, Laatikainen T, Mammarella F, Muth C, Navickas R, Prados-Torres A, Rijken M, Rothe U, Souchet L, Valderas J, Vontetsianos T, Zaletel J14, Onder G; Joint Action on Chronic Diseases and Promoting Healthy Ageing Across the Life Cycle (JA-CHRODIS). Multimorbidity care model: Recommendations from the consensus meeting of the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS). Health Policy 122(1):4-11.
2017-2014
2017
Ignatios Ioakeim, Alvaro Irigoyen von Sierakowski, Laura Urieta González, Aida Moreno Juste, Clara Laguna Berna, Francisca González Rubio. Hipovitaminosis D: Buscando la evidencia. Endocrinol Diabetes Nutr. 2017. Nov;64(9):512-513
Alexandra Prados-Torres; Isabel del Cura-González; Daniel Prados-Torres; Juan A López-Rodríguez; Francisca Leiva-Fernández; Amaia Calderón-Larrañaga; Fernando López-Verde; Luis A Gimeno-Feliu; Esperanza Escortell-Mayor; Victoria Pico-Soler; Teresa Sanz-Cuesta; Mª Josefa Bujalance-Zafra; Mariel Morey-Montalvo; José Ramón Boxó-Cifuentes; Beatriz Poblador-Plou; José Manuel Fernández-Arquero; Francisca González-Rubio; María D Ramiro-González; Carlos Coscollar-Santaliestra; Jesús Martín-Fernández; Mª Pilar Barnestein-Fonseca; José María Valderas-Martínez; Alessandra Marengoni; Christiane Muth and Multi-PAP Group. Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy: study protocol of a cluster randomized clinical trial (Multi-PAP project). Implement Sci. 2017 Apr 27;12(1):54.
Luis Andrés Gimeno-Feliu, Amaia Calderón-Larrañaga, Esperanza Díaz, Clara Laguna-Berna, Beatriz Poblador-Plou, Carlos Coscollar, Alexandra Prados-Torres. Multimorbidity and immigrant status: associations with area of origin and length of residence in host country. Family Practice, 2017, 1-5.
Daniel Prados-Torres, Isabel del Cura-González y Alexandra Prados-Torres. Hacia un modelo de atención a la multimorbilidad en atención primaria. Aten Primaria. 2017;49(5):261-262.
Prados-Torres A, Cura-González Id, Prados-Torres JD, Leiva-Fernández F, López- Rodríguez JA, Calderón-Larrañaga A, Muth C. Multimorbilidad en medicina de familia y los principios Ariadne. Un enfoque centrado en la persona .Aten Primaria. 2017;49(5):300-307.
Bousquet J., Bewick M., Cano A. et al. Building bridges for innovation in ageing: Synergies between action group of the EIP on AHA. J Nutr Health Aging. 2017;21(1):92-104.
Jordi Castellsague, Susana Perez-Gutthann, Brian Calingaert, Christine Bui, Cristina Varas-Lorenzo, Alejandro Arana, Alexandra Prados-Torres, Beatriz Poblador-Plou, Francisca Gonzalez-Rubio, Maria Giner-Soriano, Albert Roso-Llorach, Marie Linder, Anna Citarella, Oliver Scholle, Edeltraut Garbe. Characterization of new users of cilostazol in the United Kingdom, Spain, Sweden, and Germany. Pharmacoepidemiology & Drug Safety. 2017 Jun;26(6):615-624.
Amaia Calderón-Larrañaga, Davide L Vetrano, Graziano Onder, Luis A Gimeno-Feliu, Carlos Coscollar-Santaliestra, Angelo Carfí, Maria S Pisciotta, Sara Angleman, René JF Melis, Giola Santoni, Francesca Mangialasche, Debora Rizzuto, Anna-Karin Welmer, Roberto Bernabei, Alexandra Prados-Torres, Alessandra Marengoni, and Laura Fratiglioni. Assessing and measuring chronic multimorbidity in the older population: a proposal for its operationalization. J Gerontol A Biol Sci Med Sci. 2017 Oct
2016
Sarría-Santamera A, Hijas-Gómez AI, Carmona R, Gimeno-Feliú LA. A systematic review of the use of health services by immigrants and native populations. Public Health Reviews.2016;37(1):28
Marengoni A , Monaco A ,Costa E,Cherubini A,Prados-Torres A,Muth C, Melis RJ,Pasina L,van der Cammen TJ ,Palmer K,Pecorelli S,Onder G .Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board. Drugs & Aging. 2016 Sep; 33(9):629-37.
Menditto E, Bolufer A, Cahir C, Marengoni A, Riegler S, Fico G, Costa E, Monaco A, Pecorelli S, Pani L, Prados A. Scaling up health knowledge at European level requires sharing integrated data. Clinicoecon Outcomes Res. 2016 Jun 13;8:253-65.
Luis A Gimeno-Feliu, Amaia Calderón-Larrañaga, Esperanza Diaz, Beatriz Poblador-Plou, Rosa Macipe-Costa, Alexandra Prados-Torres. Global healthcare use by immigrants in Spain according to morbidity burden, area of origin, and length of stay. BMC Public Health. 2016 May 27; 16:450.
Malo S, Poblador-Pou B, Prados-Torres A, Lallana MJ, Laguna-Berna C and Rabanaque MJ. Poor congruence with guidelines in the use of antibiotics for acute bronchitis: a descriptive study based on electronic health records. Fam Pract. 2016 Oct;33(5):471-5.
Marengoni, R. J. F. Melis, A. Prados Torres, and G. Onder. “Multimorbidity: Epidemiology and Models of Care”. Biomed Res Int, vol. 2016, Article ID 7029027, 2 pages, 2016.
Gimeno LA, Calderón A, Prados A, Revilla C, Diaz E. Patterns of pharmaceutical use for immigrants to Spain and Norway: a comparative study of prescription databases in two European countries. International Journal for Equity in Health. 2016 Feb 24;15:32
Calderón A, Diaz E, Poblador B, Gimeno LA, Abad JM, Prados A. Non-adherence to antihypertensive medication: the role of mental and physical comorbidity. International Journal of Cardiology. 2016 Jan 11; 207:310-316.
Revilla C, Calderón A, Enríquez N, Prados A. Baja concordancia entre la información clínica de atención primaria y hospital. Aten Primaria. 2016 Apr;48(4):244-50.
Machón M, Egüés N, Martínez N, Abellán G, Calderón A, Aldaz P, Poblador B, Vrotsou K, Clerencia M, Prados A, Vergara I. Armonización de bases de datos para el estudio de la fragilidad en personas mayores: Estudio INTAFRADE. Rev Esp Geriatr Gerontol. 2016 Jan-Feb;51(1):29-36.
Marta J, Obón B, Gimeno LA, Achkar N, Poblador B, Calderón A, Prados A. Concordancia del registro de demencia en las principales fuentes de información clínica. Rev Esp Geriatr Gerontol. 2016 Sep-Oct;51(5):276-9.
2014
Cimarras C, Calderón A, Poblador B, González F, Gimeno L, Arjol J, Prados A. Association between physical activity, multimorbidity, self-rated health and functional limitation in the Spanish population. BMC Public Health 2014;14:1170.
Calderón A, Soljak M, Cowling T, Gaitatzis A, Majeed A. Association of primary care factors with hospital admissions for epilepsy in England, 2004-10: national observational study. Seizure 2014 Sep;23(8):657-61.
Poblador B, van den Akker M, Vos R, Calderón A, Metsemakers J, Prados A. Similar multimorbidity patterns in primary care patients from two European regions: results of a factor analysis. PLoS One 2014;9(6):e100375.
Abad JM, Calderón A, Poncel A, Poblador B, Calderón J, Sicras A, Clerencia M, Prados A. Age and gender differences in the prevalence and patterns of multimorbidity in the older population. BMC Geriatr 2014;14:75.
Poblador B, Calderón A, Marta J, Hancco J, Sicras A, Soljak M, Prados A. Comorbidity of dementia: a cross-sectional study of primary care older patients. BMC Psychiatry 2014;14(1):84.
Calderón A, Soljak M, Panna Vamos E, Cecil E, Valabhji J, Bell D, Abi-Aad G, Prados A, Majeed A. Does higher quality of primary healthcare reduce admissions for diabetes complications? A national observational study. Diabet Med 2014;31(6):657-65.
Prados A, Calderón A, Hancco J, Poblador B, van den Akker M. Multimorbidity patterns: a systematic review. J Clin Epidemiol. 2014;67(3):254-66.
Aguilar I, Carrera P, Poblador B, Prados A, Rabanaque M, por (GRISSA). Morbilidad y consumo de fármacos. Comparación de resultados entre la Encuesta Nacional de Salud y los registros electrónicos. Gac Sanit. 2014;28(1):41-7.
Proyectos activos
- Características clínico-epidemiológicas del COVID-19 en Aragón. Caracterización de grupos de riesgo e incidencia de morbilidad y mortalidad (PRECOVID Study)
- Study on impact of COVID-19 infection and medicines in pregnancy (CONSIGN)
- Strengthening use of real-world data in medicines development – metadata for data discoverability and study replicability
- CONCEPT-SURBCAN: uso de datos del mundo real para estudiar la efectividad y la eficiencia de la atención a supervivientes de cáncer de mama de larga duración
- Proyecto FIS Multicéntrico: “Efectividad de la intervención Multi-PAP Plus en ancianos jóvenes con multimorbilidad y polimedicación para mejorar la prescripción en atención primaria: ECA por conglomerados (PI18/01303)
- FAIR4Health: Improving Health Research in EU through FAIR Data
- EU Joint Action: CHRODIS-PLUS Implementing good practices for chronic diseases
- Cross National Comparison on Medication Adherence based on Observational Database. EIP-AHA
- Proyecto FIS Multicéntrico: “Efectividad de la intervención Multi-PAP en ancianos jóvenes con multimorbilidad y polimedicación para mejorar la prescripción en atención primaria: ECA por conglomerados (PI15/00276)”
- Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC RD16/0001/0005). ISCIII. Programa RETICs
- Reconocimiento como Grupo de Referencia del Gobierno de Aragón del Área de Biomédicas
Fecha actualización
Marzo 2025